Verrumal Topical Solution
Dimethyl sulphoxide, Fluorouracil, Salicylic acid
"80mg, 5mg, 100mg/ml"
HERMAL KURT HERMANN
| Pack size | 13ml Bottle |
|---|---|
| Dispensing mode | POM |
| Source | GERMANY |
| Agent | NEW MEDICAL CENTRE |
| Retail Price | 25.50 AED |
Indications
Verrumal Topical Solution is used for:
DIMETHYL SULFOXIDE
For the symptomatic relief of patients with interstitial cystitis
FLUOROURACIL
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid
SALICYLIC ACID
Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts
For the symptomatic relief of patients with interstitial cystitis
FLUOROURACIL
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid
SALICYLIC ACID
Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Dimethyl sulphoxide, Fluorouracil, Salicylic acid :
Mechanism of Action
DIMETHYL SULFOXIDE
The mechanism of dimethyl sulfoxide's actions is not well understood. Dimethyl sulfoxide has demonstrated antioxidant activity in certain biological settings. For example, the cardiovascular protective effect of dimethyl sulfoxide in copper-deficient rats is thought to occur by an antioxidant mechanism. It is also thought that dimethyl sulfoxide's possible anti-inflammatory activity is due to antioxidant action
FLUOROURACIL
The precise mechanism of action has not been fully determined, but the main mechanism of fluorouracil is thought to be the binding of the deoxyribonucleotide of the drug (fdump) and the folate cofactor, n5010-methylenetetrahydrofolate, to thymidylate synthase (ts) to form a covalently bound ternary complex. This results in the inhibition of the formation of thymidylate from uracil, which leads to the inhibition of dna and rna synthesis and cell death. Fluorouracil can also be incorporated into rna in place of uridine triphosphate (utp), producing a fraudulent rna and interfering with rna processing and protein synthesis
SALICYLIC ACID
Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (cox-1 and cox-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (udpg) competitively with nicotinamide adenosine dinucleotide (nad) and noncompetitively with udpg. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (udpga) to the phenolic acceptor. The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis
The mechanism of dimethyl sulfoxide's actions is not well understood. Dimethyl sulfoxide has demonstrated antioxidant activity in certain biological settings. For example, the cardiovascular protective effect of dimethyl sulfoxide in copper-deficient rats is thought to occur by an antioxidant mechanism. It is also thought that dimethyl sulfoxide's possible anti-inflammatory activity is due to antioxidant action
FLUOROURACIL
The precise mechanism of action has not been fully determined, but the main mechanism of fluorouracil is thought to be the binding of the deoxyribonucleotide of the drug (fdump) and the folate cofactor, n5010-methylenetetrahydrofolate, to thymidylate synthase (ts) to form a covalently bound ternary complex. This results in the inhibition of the formation of thymidylate from uracil, which leads to the inhibition of dna and rna synthesis and cell death. Fluorouracil can also be incorporated into rna in place of uridine triphosphate (utp), producing a fraudulent rna and interfering with rna processing and protein synthesis
SALICYLIC ACID
Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (cox-1 and cox-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (udpg) competitively with nicotinamide adenosine dinucleotide (nad) and noncompetitively with udpg. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (udpga) to the phenolic acceptor. The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis
Note
Verrumal "80mg, 5mg, 100mg/ml" Topical Solution manufactured by HERMAL KURT HERMANN. Its generic name is Dimethyl sulphoxide, Fluorouracil, Salicylic acid. Verrumal is availble in United Arab Emirates.
Farmaco UAE drug index information on Verrumal Topical Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.