Vibrocil Nasal Drops
Dimethindene maleate, Phenylephrine
"0.25mg, 2.5mg/ml"
Novartis Consumer Health SA
| Pack size | 15ml Bottle |
|---|---|
| Dispensing mode | P |
| Source | SWITZERLAND |
| Agent | CITY MEDICAL STORE |
| Retail Price | 11.50 AED |
Indications
Vibrocil Nasal Drops is used for:
DIMETINDENE
Indicated as symptomatic treatment of allergic reactions: urticaria, allergies of the upper respiratory tract such as hey fever and perennial rhinitis, food and drug allergies; pruritus of various origins, except pruritus due to cholestasis; insect bites. Dimethindene is also indicated for pruritus in eruptive skin diseases such as chicken-pox. Dimethindene can also be used as an adjuvant in eczema and other pruriginous dermatoses of allergic origin
PHENYLEPHRINE
Phenylephrine is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs
Indicated as symptomatic treatment of allergic reactions: urticaria, allergies of the upper respiratory tract such as hey fever and perennial rhinitis, food and drug allergies; pruritus of various origins, except pruritus due to cholestasis; insect bites. Dimethindene is also indicated for pruritus in eruptive skin diseases such as chicken-pox. Dimethindene can also be used as an adjuvant in eczema and other pruriginous dermatoses of allergic origin
PHENYLEPHRINE
Phenylephrine is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Dimethindene maleate, Phenylephrine :
Mechanism of Action
DIMETINDENE
Dimethindene is a selective histamine h1 antagonist and binds to the histamine h1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine
PHENYLEPHRINE
In general, α1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. α1-receptors are 7-transmembrane domain receptors coupled to g proteins, gq/11. Three α1-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: α1a (chromosome 8), α1b (chromosome 5), and α1d (chromosome 20). Phenylephrine appears to act similarly on all three receptor subtypes. All three receptor subtypes appear to be involved in maintaining vascular tone. The α1a-receptor maintains basal vascular tone while the α1b-receptor mediates the vasocontrictory effects of exogenous α1-agonists. Activation of the α1-receptor activates gq-proteins, which results in intracellular stimulation of phospholipases c, a2, and d. This results in mobilization of ca2+ from intracellular stores, activation of mitogen-activated kinase and pi3 kinase pathways and subsequent vasoconstriction. Phenylephrine produces its local and systemic actions by acting on α1-adrenergic receptors peripheral vascular smooth muscle. Stimulation of the α1-adrenergic receptors results in contraction arteriolar smooth muscle in the periphery. Phenylephrine decreases nasal congestion by acting on α1-adrenergic receptors in the arterioles of the nasal mucosa to produce constriction; this leads to decreased edema and increased drainage of the sinus cavities
Dimethindene is a selective histamine h1 antagonist and binds to the histamine h1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine
PHENYLEPHRINE
In general, α1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. α1-receptors are 7-transmembrane domain receptors coupled to g proteins, gq/11. Three α1-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: α1a (chromosome 8), α1b (chromosome 5), and α1d (chromosome 20). Phenylephrine appears to act similarly on all three receptor subtypes. All three receptor subtypes appear to be involved in maintaining vascular tone. The α1a-receptor maintains basal vascular tone while the α1b-receptor mediates the vasocontrictory effects of exogenous α1-agonists. Activation of the α1-receptor activates gq-proteins, which results in intracellular stimulation of phospholipases c, a2, and d. This results in mobilization of ca2+ from intracellular stores, activation of mitogen-activated kinase and pi3 kinase pathways and subsequent vasoconstriction. Phenylephrine produces its local and systemic actions by acting on α1-adrenergic receptors peripheral vascular smooth muscle. Stimulation of the α1-adrenergic receptors results in contraction arteriolar smooth muscle in the periphery. Phenylephrine decreases nasal congestion by acting on α1-adrenergic receptors in the arterioles of the nasal mucosa to produce constriction; this leads to decreased edema and increased drainage of the sinus cavities
Note
Vibrocil "0.25mg, 2.5mg/ml" Nasal Drops manufactured by Novartis Consumer Health SA. Its generic name is Dimethindene maleate, Phenylephrine. Vibrocil is availble in United Arab Emirates.
Farmaco UAE drug index information on Vibrocil Nasal Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.