Vilna Tablets / Film-coated
Sildenafil
100mg
Neopharma
| Pack size | 4's Blister |
|---|---|
| Dispensing mode | POM |
| Source | UAE |
| Agent | NEW MEDICAL CENTRE |
| Retail Price | 111.50 AED |
Available as:
Indications
Vilna Tablets / Film-coated is used for:
Erectile dysfunction, Pulmonary arterial hypertension
Adult Dose
Oral
Erectile dysfunction
Adult: 50 mg about 1 hr before sexual intercourse. May adjust dose depending on penile response.
Max: 100 mg/dose and not to be taken > once in 24 hr.
Elderly: >65 yr: Lower initial dose at 25 mg.
Hepatic impairment: Initially, 25 mg.
Pulmonary Arterial Hypertension
20 mg 3 times daily, administered 4-6 hours apart
Child Dose
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 Initially, 25 mg.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. Patients concurrently or intermittently using organic nitrates in any form.
Precautions
Caution when used in patients with anatomical deformation of penis or conditions that may predispose them to priapism (e.g. sickle cell anaemia, myeloma, or leukaemia). Mild, transient, dose-related impairment of colour discrimination (blue/green) may occur. Hepatic or severe renal impairment, bleeding disorders, active peptic ulceration, hypotension, recent history of stroke, MI, arrhythmias, unstable angina, heart failure or retinal disorders. May cause sudden loss or decrease in hearing.
Pregnancy-Lactation
Pregnancy
Limited published data from randomized controlled trials, case-controlled trials, and case series do not report a clear association with sildenafil and major birth defects, miscarriage, or adverse maternal or fetal outcomes when sildenafil is used during pregnancy; there are risks to mother and fetus from untreated pulmonary arterial hypertension
Pregnant women with untreated pulmonary arterial hypertension are at risk for heart failure, stroke, preterm delivery, and maternal and fetal death
Lactation
Limited published data from a case report describe presence of sildenafil and its active metabolite in human milk; there is insufficient information about effects of sildenafil on breastfed infant and no information on effects of sildenafil on milk production; limited clinical data during lactation preclude a clear determination of risk of drug to an infant during lactation
Interactions
Inhibitors of CYP3A4 such as cimetidine and erythromycin are likely to reduce sildenafil clearance. CYP3A4 inducers such as rifampicin may decrease the plasma concentrations of sildenafil. Symptomatic hypotension when used with beta-blockers. Plasma concentrations are increased by ritonavir.
Potentially Fatal: May potentiate hypotensive effects of of organic nitrates and nicorandil.
Adverse Effects
Side effects of Sildenafil :
>10%
Headache (7-16%)
1-10%
Flushing (4-10%), Epistaxis (8%), Dyspepsia (4-8%), Insomnia (6%), Erythema (5%), Diarrhea (4%), Dizziness (2%), Skin rash (2%)
Mechanism of Action
Sildenafil inhibits phosphodiesterase type-5 (PDE5) which is responsible for cGMP degradation in the corpus cavernosum. Inhibition of PDE5 increases cGMP levels in the corpus cavernosum which results in smooth muscle relaxation and inflow of blood to the corpus cavernosum.
Note
Vilna 100mg Tablets / Film-coated manufactured by Neopharma. Its generic name is Sildenafil. Vilna is availble in United Arab Emirates.
Farmaco UAE drug index information on Vilna Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
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