Viramune Suspension
Nevirapine
50mg/5ml
Boehringer Ingelheim GmbH
| Pack size | 240ml Plastic Bottle |
|---|---|
| Dispensing mode | POM |
| Source | GERMANY |
| Agent | GULF DRUG EST. |
| Retail Price | 299.00 AED |
Indications
Viramune Suspension is used for:
HIV infection
Adult Dose
Oral
HIV infection
Adult: Combined with other antiretrovirals: 200 mg once daily for the first 14 days; increase to 200 mg bid if rash does not develop. Interrupting the treatment for >7 days necessitate reintroduction at a lower dose for the first 14 days.
Child Dose
Oral
HIV infection
Child: Combined with other antiretrovirals: 2 mth to 8 yr: 4 mg/kg once daily for the first 14 days; increase to 7 mg/kg bid if no rash is present. 8-16 yr: 4 mg/kg once daily for 14 days followed by 4 mg/kg bid. Max: 400 mg daily. Interrupting the treatment for >7 days necessitate reintroduction at a lower dose for the first 14 days.
Renal Dose
Renal impairment: Haemodialysis: A further 200-mg dose is recommended after dialysis.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. Lactation. Severe hepatic impairment.
Precautions
Pregnancy. Interrupt treatment if severe hepatotoxicity or life-threatening skin reactions develop. Renal or hepatic insufficiency. Monitor liver function periodically.
Pregnancy-Lactation
Interactions
Mutually increased levels effects when used with drugs extensively metabolised by CYP3A. Reduced levels/effects of methadone.
Adverse Effects
Side effects of Nevirapine :
Skin rash, nausea, vomiting, headache, abnormal LFT, fatigue, diarrhoea, abdominal pain.
Potentially Fatal: Severe and life-threatening hepatotoxic and skin reactions
Mechanism of Action
Nevirapine is a non-nucleoside reverse transcriptase inhibitor that acts against HIV-1. It binds directly to reverse transcriptase and thereby blocks the RNA-dependent and DNA-dependent DNA polymerase activities by disrupting the enzyme's catalytic site.
Note
Viramune 50mg/5ml Suspension manufactured by Boehringer Ingelheim GmbH. Its generic name is Nevirapine. Viramune is availble in United Arab Emirates.
Farmaco UAE drug index information on Viramune Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.