Zarontin Syrup
Ethosuximide
250mg/5ml
PARKE DAVIS & C0 LIMITED
| Pack size | 300ml |
|---|---|
| Dispensing mode | POM |
| Source | UK |
| Agent | NEW MEDICAL CENTRE |
| Retail Price | 27.00 AED |
Available as:
Indications
Zarontin Syrup is used for:
Absence seizures
Adult Dose
Oral
Absence seizures
Adult: Initially, 500 mg daily, may increase in steps of 250 mg at intervals of 4-7 days. Usual dose: 1-1.5 g daily.
Optimum plasma concentration: 40-100 mg/L (300-700 micromol/L).
Max: Up to 2 g in some patients. Strict supervision is recommended if dose >1.5 g daily.
Hepatic Impairment
Monitor closely
Child Dose
Child: <6 yr: Initially, 250 mg daily, may increase gradually to usual dose of 20 mg/kg daily.
>6 yr: Initially, 500 mg daily, may increase in steps of 250 mg at intervals of 4-7 days.
Usual dose: 1-1.5 g daily. Max: <6 yr: Up to 1 g/day and ?6 yr: 2 g/day .
Renal Dose
Renal Impairment
Monitor closely
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. Pregnancy and lactation.
Precautions
Hepatic or renal impairment, porphyria. Complete blood cell count, liver function tests, and urinalysis should be performed periodically. May increase the risk of grand mal seizures when used alone in mixed types of epilepsy. Avoid sudden withdrawal. May impair ability to drive or operate machinery.
Lactation: enters breast milk; use with caution (AAP Committee states "compatible with nursing")
Pregnancy-Lactation
Pregnancy Category: C
Lactation: enters breast milk; use with caution (AAP Committee states "compatible with nursing")
Interactions
Isoniazid may increase the serum concentration of ethosuximide, leading to toxicity. Antipsychotics, antidepressants, MAOIs, and mefloquine may antagonise anticonvulsant effects of ethosuximide. Plasma conc of ethosuximide may be reduced by carbamazepine, phenobarbital, phenytoin, and primidone; and affected by valproate. Chloroquine or hydroxychloroquine may increase risk of convulsions. Isoniazid.
Adverse Effects
Side effects of Ethosuximide :
Common
Dizziness, Headache, Somnolence, Anorexia, Diarrhea, GI upset, Nausea, Vomiting
Less Common
Ataxia, confusion, drowsiness, sleep disturbance, Gum hypertrophy, hiccoughs, swelling of tongue, Blood dyscrasias including aplastic anemia, Allergic reaction, Urticaria, Pruritic erythematous rashes, Blurred vision, myopia
Rare
Psychosis, Seizure, Suicidal thoughts and behavior, Stevens-Johnson syndrome, Systemic lupus erythematosus, Hirsutism
Mechanism of Action
Ethosuximide is used mainly in the management of absence (petite mal) seizures. It is usually ineffective in the management of partial seizures with complex symptomatology or tonic-clonic seizures.
Note
Zarontin 250mg/5ml Syrup manufactured by PARKE DAVIS & C0 LIMITED. Its generic name is Ethosuximide. Zarontin is availble in United Arab Emirates.
Farmaco UAE drug index information on Zarontin Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.