Zovirax 3% Eye Ointment
Acyclovir 3% Eye prep30mg/g
The Wellcome Foundation Limited
|AL BAKER TRADING EST.
Zovirax 3% Eye Ointment is used for: Herpes simplex keratitis
As 3% Eye oint: Apply 5 times/day until 3rd day of complete healing.
Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration.
Pregnancy A prospective epidemiologic registry of acyclovir use from 1984-1999 reported birth defects in women exposed to systemic acyclovir during the first trimester of pregnancy Likewise, oral and SC administration of acyclovir to pregnant mice, rats, and rabbits during organogenesis did not produce teratogenicity at clinically relevant doses Lactation Acyclovir concentrations reported in breast milk following oral administration of acyclovir There is no information regarding presence of acyclovir in human milk following ocular administration, effects on the breastfed infant, or effects on milk production Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug, and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal condition
Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).
Side effects of Acyclovir 3% Eye prep : Eye application may produce stinging, superficial punctate keratopathy, blepharitis or conjunctivitis.
Mechanism of Action
Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.
Zovirax 3% 30mg/g Eye Ointment manufactured by The Wellcome Foundation Limited. Its generic name is Acyclovir 3% Eye prep. Zovirax 3% is availble in United Arab Emirates. Farmaco UAE drug index information on Zovirax 3% Eye Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.