Zpdex Tablets / Film-coated

Cefpodoxime

100mg

LUPIN LIMITED

Pack size	10's Blister
Dispensing mode	POM
Source	INDIA
Agent	PHARMALINK
Retail Price	20.50 AED

Available as:

200mg - Tablets / Film-coated

Indications

Zpdex Tablets / Film-coated is used for: Pharyngitis, Acute otitis media, Community-acquired pneumonia, Sinusitis, UTI, Cystitis, Gonorrhea, Skin and skin structure infections, Tonsillitis, Respiratory tract infections, Acute Maxillary Sinusitis, Acute bacterial exacerbation of chronic bronchitis

Adult Dose

Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Acute Maxillary Sinusitis 200 mg PO q12hr for 10 days Acute Community-Acquired Pneumonia 200 mg PO q12hr for 14 days Pharyngitis/Tonsillitis 100 mg PO q12hr for 5-10 days Skin/Skin Structure Infections 400 mg PO q12hr for 7-14 days Uncomplicated gonorrhoea 200 mg as a single dose Uncomplicated Urinary Tract Infections 100 mg PO q12hr for 7-14 days Hepatic impairment Dosage adjustment not necessary

Child Dose

Child : PO 10 mg/kg/day, max 400 mg/day q12h 6 months - 2 years : 40 mg every 12 hours 3 - 8 years : 80 mg every 12 hours over 9 years : 100 mg every 12 hours

Renal Dose

Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session. CrCl (ml/min) Dosage Recommendation 10-39 Increase dosing intervals to 24 hrly. <10 Increase dosing intervals to 48 hrly.

Administration

Should be taken with food. Take after meals. Reconstitution: Reconstitute powd for oral susp at the time of dispensing by adding the amount of water specified on the container to provide a susp containing 50 mg or 100 mg per 5 mL. Add water in 2 equal parts and shake the bottle vigorously after each addition.

Contra Indications

Hypersensitivity.

Precautions

History of allergy to penicillin; severe renal impairment; pregnancy and lactation. Lactation: Drug excreted in breast milk in low concentrations; not recommended

Pregnancy-Lactation

Pregnancy category: B Lactation: Drug excreted in breast milk in low concentrations; not recommended

Interactions

Antacids or H2-blockers may decrease the absorption of cefpodoxime. Probenecid inhibits renal excretion. Potentially Fatal: Monitor renal function during admin. Additive nephrotoxic effects with furosemide.

Adverse Effects

Side effects of Cefpodoxime : >10% Diarrhea in infants and toddlers (15.4%), Diaper rash (12.1%) 1-10% Diarrhea (7.4%), Nausea (3.8%), Vaginal infection (3.1%), Vomiting (1.1-2.1%), Abdominal pain (1.6%), Rash (1.4%), Headache (1.1%) Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.

Mechanism of Action

Cefpodoxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Note

Zpdex 100mg Tablets / Film-coated manufactured by LUPIN LIMITED. Its generic name is Cefpodoxime. Zpdex is availble in United Arab Emirates. Farmaco UAE drug index information on Zpdex Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Cefpodoxime :

Tablets / Film-coated

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Tablets

Zakon ^200mg

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Suspension

Zakon ^100mg/5ml

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Suspension

Zakon ^100mg/5ml

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