Zyfast Tablets / Film-coated
Etoricoxib
60mg
OMAN PHARMACEUTICAL PRODUCTS CO. L.L.C
| Pack size | 28's (7's Blister x 4) |
|---|---|
| Dispensing mode | POM |
| Source | OMAN |
| Agent | Alphamed Drug Store |
| Retail Price | 57.50 AED |
Available as:
Indications
Zyfast Tablets / Film-coated is used for:
Rheumatoid arthritis, Osteoarthritis, Gout
Adult Dose
Oral
Osteoarthritis
Adult: 30 mg once daily, increased to 60 mg once daily if needed.
Ankylosing spondylitis; Rheumatoid arthritis
Adult: 90 mg once daily.
Acute gout
Adult: 120 mg once daily. Max duration: 8 days.
Hepatic impairment: Mild (Child-Pugh score of 5-6): 60 mg once daily.
Moderate (Child-Pugh 7-9): Max 60 mg every other day or 30 mg once daily.
Severe (Child-Pugh >10): Avoid.
Child Dose
Child: <16 yr Contraindicated.
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Inflammatory bowel disease, severe congestive heart failure, active peptic ulceration, cerebrovascular disease, CrCL <30 ml/min; lactation. Children and adolescent < 16 yr.
Precautions
Allergic disorders, coagulation defects; history of cardiac failure, left ventricular dysfunction, hypertension, or in patients with oedema due to other reasons; elderly, renal, cardiac or hepatic impairment. Withdraw treatment if GI lesions develop; caution when admin to dehydrated patients. Regular BP monitoring is advisable. May mask fever and other signs of infection. Pregnancy.
Pregnancy-Lactation
Interactions
May increase INR w/ oral anticoagulants. May decrease effects of ACE inhibitors, angiotensin II antagonist and diuretics. May increase lithium plasma concentrations. May reduce plasma levels w/ rifampicin. Increased serum concentrations of ethinylestradiol.
Adverse Effects
Side effects of Etoricoxib :
GI disorders; ischemic cardiac events; hypersensitivity reactions, headache, dizziness, nervousness, depression, drowsiness, insomnia, vertigo, tinnitus, photosensitivity; blood disorders, fluid retention, hypertension; dry mouth, taste disturbance, mouth ulcers; appetite and wt changes; chest pain, fatigue, paraesthesia, influenza-like syndrome, myalgia. Renal toxicity.
Mechanism of Action
Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to inhibition of prostaglandin synthesis via inhibition of COX-2.
Note
Zyfast 60mg Tablets / Film-coated manufactured by OMAN PHARMACEUTICAL PRODUCTS CO. L.L.C . Its generic name is Etoricoxib. Zyfast is availble in United Arab Emirates.
Farmaco UAE drug index information on Zyfast Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.