Zyncor Tablets / Film-coated
Bisoprolol
5mg
Oman Pharmaceutical Products
| Pack size | 28's (14's Blister x 2) |
|---|---|
| Dispensing mode | POM |
| Source | OMAN |
| Agent | Muscat Pharmaceutical Trading L.L.C. |
| Retail Price | 18.00 AED |
Available as:
Indications
Zyncor Tablets / Film-coated is used for:
Hypertension, Angina pectoris, Congestive heart failure
Adult Dose
The usual starting dose is 5 mg once daily. In some patients, 2.5 mg may be an appropriate starting dose.
If the antihypertensive effect of 5 mg is inadequate, the dose may be increased to 10 mg and then, if necessary, to 20 mg once daily.
For heart failure: Initially 1.25 mg once daily (in the morning) for 1 week then, if well tolerated, increased to 2.5 mg once daily for 1 week, then 3.75 mg once daily for 1 week, then 5 mg once daily for 4 weeks, then 7.5 mg once daily for 4 weeks, then 10 mg once daily; max. 10 mg daily.
Hepatic impairment: Severe: Initially, 2.5 mg/day. Max: 10 mg/day.
Elderly: Hypertension
2.5-20 mg PO qDay
Heart Failure
1.25 mg PO qDay; not to exceed 10 mg/day
Child Dose
Renal Dose
Renal impairment:
CrCl (ml/min)
<40 Initial: 2.5 mg/day.
Administration
May be taken with or without food.
Contra Indications
Patients with cardiogenic shock, overt cardiac failure, second or third degree AV block and marked sinus bradycardia.
Precautions
Impaired Renal or Hepatic Function.
Lactation: excretion in milk unknown; use caution
Pregnancy-Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use caution
Interactions
May potentiate AV conduction time and may increase negative inotropic effect w/ class I antiarrhythmic drugs (e.g. quinidine, disopyramide, propafenone). Concomitant catecholamine-depleting drugs (e.g. reserpine, guanethidine) may produce excessive sympathetic activity. May exacerbate rebound HTN upon discontinuance of clonidine treatment. Increased risk of bradycardia w/ digitalis glycosides. Reduced hypotensive effect w/ NSAIDs.
Adverse Effects
Side effects of Bisoprolol :
1-10%
Dizziness (10%), Dyssomnia (8%-10%), Bradyarrhythmia (9%), Upper respiratory infection (5%), Diarrhea (4%), Rhinitis (4%), Arthralgia (3%), Cough (3%), Dyspnea (2%), Nausea (2%), Pharyngitis (2%), Sinusitis (2%), Vomiting (2%)
<1%
Cold extremities, Hypotension, Depression, Dyspepsia, Bronchospasm
Frequency Not Defined
Aggravate CHF, Decrease HDL, Hypertriglyceridemia, Mask symptoms of hypoglycemia, Decreased exercise tolerance, Raynaud's phenomenon, May increase triglyceride levels and insulin resistance
Mechanism of Action
Bisoprolol selectively and competitively blocks beta1-receptors but has little or no effect on beta2-receptors except at high doses.
Note
Zyncor 5mg Tablets / Film-coated manufactured by Oman Pharmaceutical Products. Its generic name is Bisoprolol. Zyncor is availble in United Arab Emirates.
Farmaco UAE drug index information on Zyncor Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
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