Acrivastine + Pseudoephedrine

Indications

Acrivastine + Pseudoephedrine is used for: Seasonal Allergic Rhinitis, Nasal Congestion

Adult Dose

Seasonal Allergic Rhinitis or Nasal Congestion 8 mg/60 mg (1 capsule) PO q4-6h >14 days continuous treatment efficacy not adequately investigated

Child Dose

Seasonal Allergic Rhinitis or Nasal Congestion <12 years: Safety and efficacy not established >12 years: 8 mg/60 mg (1 capsule) PO q4-6h >14 days continuous treatment efficacy not adequately investigated

Renal Dose

Renal Impairment CrCl>48mL/min: Dose adjustment not necessary CrCl <48mL/min: Not recommended

Administration

Contra Indications

Hypersensitivity to acrivastine or other alkylamine antihistamines Hypersensitivity to pseudoephedrine or other sympathomimetic amines Severe hypertension Severe coronary artery disease Patients taking monoamine oxidase (MAO) inhibitors and for 14 days after stopping use of an MAO inhibitor

Precautions

Due to potential for sedation, assess individual responses before engaging in any activity requiring mental alertness, such as driving a motor vehicle or operating machinery Concurrent use with alcohol or other CNS depressants may cause additional reductions in alertness and impairment of CNS performance and should be avoided Not adequately studied for relieving common cold symptoms

Pregnancy-Lactation

Pregnancy Category: B Lactation: Unknown whether acrivastine is distributed in breast milk, caution advised ; pseudoephedrine is excreted in human milk, caution advised

Interactions

Adverse Effects

Side effects of Acrivastine + Pseudoephedrine : 1-10% Somnolence Nervousness Insomnia Dry mouth <1% Headache Dizziness Asthenia Nausea Dyspepsia Pharyngitis Cough increase Dysmenorrhea

Mechanism of Action

Acrivastine exhibits H1-antihistaminic receptor activity, which prevents histamine from binding to its receptor in target cells Pseudoephedrine: Indirect sympathomimetic agent, releases norepinephrine from adrenergic nerves