Adapalene 0.1% Topical


Adapalene 0.1% Topical is used for: Acne, Keratosis pilaris

Adult Dose

Adult: Topical As 0.1% soln/cream/gel: Apply once daily at night after cleansing.

Child Dose

Renal Dose


Apply small (pea-sized) amount sparingly to entire face after cleansing with nonmedicated cleanser. For topical use only;

Contra Indications



Patients with sunburn, eczema. Pregnancy, lactation. Avoid excessive exposure to sunlight or UV irradiation. Keep away from the eyes, lips, nostrils and mucous membranes. Do not apply to cuts, abrasions, scaly or flaky skin, or patches of sunburned skin. Use with caution with preparations containing sulfur, resorcinol, or salicylic acid. Lactation: Excretion in milk unknown; use with caution.


Pregnancy category: C Lactation: Excretion in milk unknown; use with caution


Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents.

Adverse Effects

Side effects of Adapalene 0.1% Topical : >10% Dryness (1-45%), Scaling (1-44%), Burning/stinging (4-29%), Erythema (0.5-26%) 1-10% Skin discomfort (6%), Pruritus (2%), Desquamation (2%), Sunburn (1%) <1% Acne flare, Conjunctivitis, Contact dermatitis, Eczema, Erythema, Eyelid edema, Rash, Skin discoloration

Mechanism of Action

Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.