Alclometasone topical
Indications
Alclometasone topical is used for:
Corticosteroid-responsive dermatoses, Inflammatory & Pruritic Skin Disorders
Adult Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.05% cream/oint: Apply sparingly a thin film onto the affected area 2-3 times daily, for up to 7 days. Longer duration of treatment w/ appropriate monitoring may be necessary in patients w/ resistant or chronic conditions.
Do not use for >3 wk.
Child Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Child: >1 yr As 0.05% cream/oint: Apply sparingly a thin film onto the affected area 2-3 times daily, for up to 7 days. Longer duration of treatment w/ appropriate monitoring may be necessary in patients w/ resistant or chronic conditions.
Do not use for >3 wk.
Renal Dose
Administration
Contra Indications
Broken skin, tuberculous or viral (e.g. herpes simplex, vaccinia, varicella) skin lesions, fungal (e.g. candidiasis, tinea) or bacterial (e.g. impetigo) skin infections, rosacea, acne, perioral dermatitis.
Precautions
Patient w/ seborrhoeic dermatitis, psoriasis. Childn. Pregnancy and lactation. Patient Counselling Do not apply on the face, eyes, underarm, groin, breast-fold, genitals, or between the toes. Monitoring Parameters Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression thru ACTH stimulation test, plasma cortisol test, and urinary free cortisol test.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: It is not known whether topical administration of topical corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Use with caution.
Interactions
Adverse Effects
Side effects of Alclometasone topical :
Frequency Not Defined
Skin atrophy
Hypopigmentation
Miliaria
Cushing's syndrome
Dryness
Striae
Acneform lesions
Secondary infection
Irritation
HPA suppression (with higher potency used >2 wk)
Mechanism of Action
Alclometasone, a synthetic glucocorticoid, induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, thereby depressing the biosynthesis and activity of prostaglandins, leukotrienes, and other inflammatory mediators.