Alfuzosin + Dutasteride
Indications
Alfuzosin + Dutasteride is used for:
Benign Prostatic Hyperplasia (BPH)
Adult Dose
Oral
1 tablet once a day
Child Dose
Renal Dose
Administration
Should be taken with food. Take immediately after the same meal each day.
Contra Indications
History of orthostatic hypotension. Severe hepatic impairment. Concurrent use w/ potent CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, ritonavir).
Precautions
Mild to moderate hepatic impairment. Prostatic carcinoma should be ruled out before starting therapy. Not intended for use in women and childn. Patient Counselling May impair ability to drive, operate machinery or perform hazardous tasks. Monitoring Parameters Monitor BP regularly and urine flow.
Pregnancy-Lactation
Interactions
Additive effect on QT interval prolongation when used w/ QT-prolonging drugs. Concomitant admin w/ other α1-adrenergic blocking agents, atenolol or diltiazem may result in additive CV effects. Increased plasma alfuzosin concentrations w/ cimetidine.
Potentially Fatal: Concurrent use w/ potent CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, ritonavir) increase plasma alfuzosin levels.
Adverse Effects
Side effects of Alfuzosin + Dutasteride :
Postural hypotension, tachycardia, angina pectoris in patient w/ pre-existing coronary artery disease, chest pain oedema, diarrhoea, upper resp tract infection, rhinitis, bronchitis, sinusitis, pharyngitis, hepatocellular and cholestatic liver injury including jaundice, dizziness, headache, fatigue, rash, pruritus, urticaria, impotence, decreased libido, ejaculation disorder, breast disorders (e.g. tenderness, enlargement), breast cancer, hypersensitivity reactions (e.g. rash, pruritus, urticaria, localised oedema, serious skin reactions, angioedema), depressed mood, testicular pain and swelling, decreased prostate-specific antigen (PSA) concentration. Rarely, priapism can occur.
Mechanism of Action
Alfuzosin is a quinazoline derivative which exhibits selectivity for α1-adrenergic receptors in the lower urinary tract. Blockade of these adrenoreceptors causes relaxation of smooth muscle in the bladder neck and prostate, resulting in improvement in urine flow and a reduction in symptoms of benign prostatic hyperplasia (BPH).
Dutasteride, a 4-azo analog of testosterone, is a selective inhibitor of steroid 5α-reductase isoenzymes type 1 (skin and hepatic) and type 2 (reproductive tissues). This results in inhibition of the conversion of testosterone to dihydrotestosterone and markedly suppresses serum dihydrotestosterone levels.