Alteplase (Recombinant Human Tissue-Type Plasminogen Activator)
Indications
Alteplase (Recombinant Human Tissue-Type Plasminogen Activator) is used for:
For management of acute myocardial infarction, acute ischemic strok and for lysis of acute pulmonary emboli
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Alteplase (Recombinant Human Tissue-Type Plasminogen Activator) :
Mechanism of Action
Alteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.