Aluminium Hydroxide
Indications
Aluminium Hydroxide is used for:
Heartburn, Indigestion, Gastric Hyperacidity, Peptic ulcer disease,
Adult Dose
Oral
Adult: Up to 1 g daily.
Hyperphosphataemia in patients with chronic renal failure
Adult: Dose is adjusted to the individual patient's requirement. Up to 10 g/day may be given in divided doses with meals.
Max Dosage: 10 g daily in divided doses.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity to aluminium salts.
Precautions
Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage. Administer 2-3 hrs before/after another medication to minimise drug interactions. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Adverse Effects
Side effects of Aluminium Hydroxide :
Constipation; intestinal obstruction (with large doses); phosphate depletion may occur with prolonged admin or large doses.
Mechanism of Action
Alumunium hydroxide acts on the HCl in the stomach by neutralization, forming aluminium chloride salt and water.