Aluminium Hydroxide + Magnesium Hydroxide
Indications
Aluminium Hydroxide + Magnesium Hydroxide is used for:
Heartburn, Reflux oesophagitis, Hyperacidity, Peptic ulcer, Constipation, Indigestion
Adult Dose
Adult: PO Gastric Hyperacidity, Heartburn: Up to 1 g/day.
Hyperphosphataemia in chronic renal failure Up to 10 g/day in divided doses w/ meals.
10-20 mL PO between meals & qHS
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity to aluminium salts.
Precautions
Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage. Administer 2-3 hrs before/after another medication to minimise drug interactions. Pregnancy and lactation.
Lactation: excretion in milk unknown; use caution
Pregnancy-Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use caution
Interactions
Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Magnesium Hydroxide: Decreases absorption of tetracyclines and biphosphonates. Separate administration of these and other drugs by around 2 hr.
Adverse Effects
Side effects of Aluminium Hydroxide + Magnesium Hydroxide :
>10%
Aluminum oxide, Chalky taste, Constipation, Fecal impaction, Stomach cramps
Frequency Not Defined
Aluminum oxide, Nausea, Vomiting, Aluminum intoxication, Hypophosphatemia, Osteomalacia, Magnesium oxide, Diarrhea, Hypermagnesemia
Mechanism of Action
Alumunium hydroxide acts on the HCl in the stomach by neutralization, forming aluminium chloride salt and water.
Magnesium hydroxide increases peristaltic activity causing osmotic retention of fluids, thus resulting in bowel evacuation. It also reduces stomach acid by reacting with hydrochloric acid to form Mg chloride.