Aluminium Hydroxide + Magnesium Trisilicate
Indications
Aluminium Hydroxide + Magnesium Trisilicate is used for:
Heartburn, Indigestion, Gastric Hyperacidity, Peptic ulcer disease, Gastroesophageal reflux disorder (GERD)
Adult Dose
Chew 2 to 4 tablets after meals and at bedtime as needed (up to 4 times a day).
Do not take more than 16 tablets in 24 hours
Child Dose
<12 years: Not recommended
Renal Dose
Administration
After meals and at bedtime as needed. For best results, drink a half glass of water or other liquid after each dose.
Contra Indications
Hypophosphataemia.
Precautions
Renal dysfunction, low phosphate diet, prolonged use.
Lactation: Unknown whether distributed in breast milk
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Unknown whether distributed in breast milk
Interactions
Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Magnesium Trisilicate: None well documented.
Adverse Effects
Side effects of Aluminium Hydroxide + Magnesium Trisilicate :
>10%
Aluminum, Chalky taste, Constipation, Fecal impaction, Stomach cramps
1-10%
Aluminum
Nausea, Vomiting, Aluminum intoxication, Hypophosphatemia, Osteomalacia, Magnesium, Diarrhea, Hypermagnesemia
Mechanism of Action
Aluminum hydroxide: Neutralizes stomach hydrocloride to form AlCl3 salt plus water; increases gastric pH.
Magnesium Trisilicate neutralizes gastric acidity by increasing gastric pH