Aluminium Oxide + Magnesium Trisilicate
Indications
Aluminium Oxide + Magnesium Trisilicate is used for:
Heartburn, Indigestion, Gastric Hyperacidity, Peptic ulcer disease, Gastroesophageal reflux disorder (GERD)
Adult Dose
Take 2-4 tsf after meals and at bedtime as needed (up to 4 times a day).
Child Dose
Renal Dose
Administration
After meals and at bedtime as needed.
Contra Indications
Hypophosphataemia.
Precautions
Renal dysfunction, low phosphate diet, prolonged use.
Pregnancy-Lactation
Interactions
Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Magnesium Trisilicate: None well documented.
Adverse Effects
Side effects of Aluminium Oxide + Magnesium Trisilicate :
Diarrhoea, constipation, nausea, vomiting.
Mechanism of Action
Aluminum hydroxide: Neutralizes stomach hydrocloride to form AlCl3 salt plus water; increases gastric pH. Magnesium Trisilicate neutralizes gastric acidity by increasing gastric pH