Amcinonide topical
Indications
Amcinonide topical is used for:
Corticosteroid-responsive dermatoses
Adult Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.1% cream/oint/lotion: Apply sparingly in a thin film to affected area bid or tid, depending on the severity of the condition.
Child Dose
Corticosteroid-Responsive Dermatoses
Apply sparingly to affected area(s) q12hr
Limit to minimum amount necessary for therapeutic efficacy
Avoid face
Renal Dose
Administration
Contra Indications
Underlying infection
Hypersensitivity
Use on groin, face, or axila
Ophthalmic use
Precautions
Childn. Pregnancy and lactation. Patient Counselling Do not use on the face, groin, or axilla. Avoid use of occlusive dressings in the presence of infected or weeping lesions. Monitoring Parameters Perform urinary free cortisol and ACTH stimulation tests to monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression if drug is applied to a large surface area or under an occlusive dressing.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: It is not known whether topical administration of topical corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Use with caution.
Interactions
Adverse Effects
Side effects of Amcinonide topical :
Frequency Not Defined
Skin atrophy
Striae
Burning
Dryness
Irritation
Itching
Hypertrichosis
Acneform lesions
Secondary infection
Pigmentation changes
HPA suppression (with higher potency used >2 wk)
Mechanism of Action
Amcinonide, a synthetic fluorinated glucocorticoid, has anti-inflammatory, antipruritic, and vasoconstrictive actions. It induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, thereby depressing the formation, release, and activity of endogenous chemical mediators of inflammation.