Amino Acids (5 % & 10%) + D-sorbitol + Electrolytes
Indications
Amino Acids (5 % & 10%) + D-sorbitol + Electrolytes is used for:
Protein supply for parenteral nutrition. Prophylaxis & therapy of protein deficiency resulting from increased protein losses &/or increased protein requirements.
Adult Dose
Adults:
10-20 mL/kg body wt (equiv to 1-2 g amino acids/kg body wt). Max infusion rate: 1 mL/kg body wt/hr (equiv to 0.1 g amino acid/kg body wt & hr).
Max daily dose: 20 mL/kg body wt (equiv to 2 g amino acid/kg body wt).
Child Dose
Infants and Children:
In children and infants, the rate of infusion is 28-35 ml/kg body wt/day is recommended, with a stepwise increment in the rate of administration during the first week of treatment.
Renal Dose
Administration
Depending upon patients requirements, 1000-2000 ml amino acid may be infused intravenously per 24 hours. It should be infused slowly, at rates 1.4-2.8 ml (30-60 drops) per minute.
Contra Indications
Contraindicated in patients with inborn errors of amino acids metabolism. Moreover, amino acid should not be used in patients with hepatic coma or metabolic disorders involving impaired nitrogen utilization.
Precautions
Hyperphenylalaninemia has been noted in severely ill, premature infants. In these patients, monitoring of the phenylalanine levels is recommended and the infusion rate adjusted as needed.
Do not use if the solution is turbid or contains particles. Discard any unused portion.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Unknown whether distributed in breast milk
Interactions
Adverse Effects
Side effects of Amino Acids (5 % & 10%) + D-sorbitol + Electrolytes :
It is usually well tolerated. Yet nausea, vomiting, flushing and sweating have been observed during infusion of amino acid IV at rates exceeding the recommended maximal rate. Hypersensitivity reactions have been reported. Like all hypertonic infusion solution, thrombophlebitis may occur when peripheral veins are used. The incidence may be reduced by the simultaneous infusion of 10% fat emulsion. If it is infused to severely ill patients, premature infants, hyperphenylalaninemia may occur.
Mechanism of Action
A crystalline amino acid solution provides crystalline amino acids to promote protein synthesis and wound healing, and to reduce the rate of endogenous protein catabolism. Amino Acids , given by central venous infusion in combination with concentrated dextrose, electrolytes, vitamins, trace metals, and ancillary fat supplements, constitutes total parenteral nutrition (TPN). Amino Acids can also be administered by peripheral vein with dextrose and maintenance electrolytes.