Amino Acids (5%) + Sorbitol + Vitamins + Electrolytes

Indications

Amino Acids (5%) + Sorbitol + Vitamins + Electrolytes is used for: It is indicated as a source of amino acids for protein synthesis in patients needing intravenous nutrition. It is particularly suitable for a patient with basal amino acid requirements. Also indicated in faster recovery in surgery, burns, renal insufficiency, hepatic insufficiency and effective management of Cancer.

Adult Dose

Adults: 10-20 mL/kg body wt (equiv to 1-2 g amino acids/kg body wt). Max infusion rate: 1 mL/kg body wt/hr (equiv to 0.1 g amino acid/kg body wt & hr). Max daily dose: 20 mL/kg body wt (equiv to 2 g amino acid/kg body wt). The nitrogen requirement for maintenance of body protein mass depends on the patient's condition (nutritional state and degree of metabolic stress). No or minor metabolic stress and normal nutritional state: 0.10-0.15 g nitrogen/kg/day, Moderate metabolic stress with or without malnutrition: 0.15-0.20 g nitrogen/kg/day, Severe catabolism as in burns, sepsis and trauma: up to 0.20-0.25 g nitrogen/kg/day. The dosage range 0.10-0.25 g nitrogen/kg/day corresponds to 15-35 ml IV/kg/day. In obese patients, the dose should be based on the estimated ideal weight. Depending upon patients requirements, 1000-2000 ml may be infused intravenously per 24 hours. It should be infused slowly, at rates 1.4-2.8 ml (30-60 drops) per minute.

Child Dose

In children and infants, the rate of infusion is 28-35 ml/kg body wt/day is recommended, with a stepwise increment in the rate of administration during the first week of treatment.

Renal Dose

Administration

Contra Indications

Precautions

Hyperphenylalaninemia has been noted in severely ill, premature infants. In these patients, monitoring of the phenylalanine levels is recommended and the infusion rate adjusted as needed. Do not use if the solution is turbid or contains particles. Discard any unused portion.

Pregnancy-Lactation

Pregnancy Category: C Lactation: Unknown whether distributed in breast milk

Interactions

Adverse Effects

Side effects of Amino Acids (5%) + Sorbitol + Vitamins + Electrolytes : Usually well tolerated. Yet nausea, vomiting, flushing and sweating have been observed during infusion, at rates exceeding the recommended maximal rate. Hypersensitivity reactions have been reported. Like all hypertonic infusion solution, thrombophlebitis may occur when peripheral veins are used. The incidence may be reduced by the simultaneous infusion of 10% fat emulsion. If it is infused to severely ill patients, premature infants, hyperphenylalaninemia may occur.

Mechanism of Action

A crystalline amino acid solution provides crystalline amino acids to promote protein synthesis and wound healing, and to reduce the rate of endogenous protein catabolism. Amino Acids , given by central venous infusion in combination with concentrated dextrose, electrolytes, vitamins, trace metals, and ancillary fat supplements, constitutes total parenteral nutrition (TPN). Amino Acids can also be administered by peripheral vein with dextrose and maintenance electrolytes.