Amino Acids 7 % + Glucose + Electrolytes 10 %
Indications
Amino Acids 7 % + Glucose + Electrolytes 10 % is used for:
Prevent nitrogen loss, Negative nitrogen balance, Nutritional therapy
Adult Dose
For peripheral intravenous infusion, 1 to 1.5 g/kg/day of total amino acids will reduce protein catabolism.
Child Dose
As reported the dosage and constant infusion rate of intravenous dextrose must be selected with caution in pediatric patients, particularly neonates and low birth weight infants, because of the increased risk of hyperglycemia/hypoglycemia.
Renal Dose
Administration
As with all intravenous fluid therapy, the primary aim is to provide sufficient water to compensate for insensible, urinary, and other fluid losses (nasogastric suction, fistula drainage, and diarrhea). Infused at a rate of 45 mL/kg/day, will meet the fluid and amino acid requirements of the stable adult patient.
As reported the dosage and constant infusion rate of intravenous dextrose must be selected with caution in pediatric patients, particularly neonates and low birth weight infants, because of the increased risk of hyperglycemia/hypoglycemia.
Contra Indications
This preparation should not be used in patients with hepatic coma or metabolic disorders involving impaired nitrogen utilization.
Precautions
Special care must be taken when administering glucose solutions to provide calories in diabetic or prediabetic patients. To control and minimize possible hyperglycemia and consequent glycosuria, it is desirable to monitor blood and urine glucose and, if necessary, add insulin.
Because of its antianabolic activity, concurrent administration of tetracycline may reduce the nitrogen sparing effects of infused amino acids.
Feeding regimens which include amino acids should be used with caution in patients with history of renal disease, pulmonary disease, or with cardiac insufficiency so as to avoid excessive fluid accumulation.
Nitrogen intake should be carefully monitored in patients with impaired renal function.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Unknown whether distributed in breast milk
Interactions
Adverse Effects
Side effects of Amino Acids 7 % + Glucose + Electrolytes 10 % :
It can be infused through a peripheral vein paying great care to the possible occurrence of local reactions. Local reactions consisting of a warm sensation, erythema, phlebitis and thrombosis at the infusion site have occurred with peripheral intravenous infusion of amino acids; in such cases the infusion site should be changed promptly to another vein. Use of large peripheral veins, inline filters, and slower rates of infusion may reduce the incidence of local venous irritation. Electrolyte additives should be spread throughout the day. Irritating additive medications may need to be injected at another venous site.
Generalized flushing, fever and nausea have been reported during peripheral infusions of amino acid solutions.
Mechanism of Action
A crystalline amino acid solution provides crystalline amino acids to promote protein synthesis and wound healing, and to reduce the rate of endogenous protein catabolism. Amino Acids , given by central venous infusion in combination with concentrated dextrose, electrolytes, vitamins, trace metals, and ancillary fat supplements, constitutes total parenteral nutrition (TPN). Amino Acids can also be administered by peripheral vein with dextrose and maintenance electrolytes.