Anhydrous Glucose + Potassium Chloride + Sodium Chloride + Sodium Bicarbonate
Indications
Anhydrous Glucose + Potassium Chloride + Sodium Chloride + Sodium Bicarbonate is used for:
Diarrhea, Gastro-enteritis with dehydration, Prolonged vomiting, Burns with a gastric fistula, Pulmonary hemorrhage, Intestinal bleeding
Adult Dose
Adult: After each loose stool or vomiting 200-400 ml of prepared saline.
Child Dose
Children less than 2 years: After each loose stool or vomiting 10 to 20 spoonful (50-100 ml).
Children 2 to 10 years: After each loose stool or vomiting 100-200 ml of prepared oral saline.
Children above 10 years: After each loose stool or vomiting 200-400 ml of prepared saline.
Renal Dose
Administration
Contra Indications
None known.
Precautions
Depressed renal function, severe continuing diarrhoea or other critical fluid losses may need supplementation with parenteral fluids along with oral saline.
Solutions containing acetate or gluconate ions should be used with caution, as excess administration may result in metabolic alkalosis.
Solutions containing dextrose should be used with caution in patients with known subclinical or overt diabetes mellitus.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Anhydrous Glucose + Potassium Chloride + Sodium Chloride + Sodium Bicarbonate :
Mechanism of Action
Oral rehydration salts are given orally to prevent or treat dehydration due to acute diarrhoea. Essential water and salts are lost in stools and vomitus, and dehydration results when blood volume is decreased because of fluid loss from the extracellular fluid compartment. Preservation of the facilitated glucose-sodium cotransport system in the small-bowel mucosa is the rationale of oral rehydration therapy. Glucose is actively absorbed in the normal intestine and carries sodium with it in about an equimolar ration. Therefore, there is a greater net absorption of an isotonic salt solution with glucose than one without it.
Potassium replacement during acute diarrhoea prevents below-normal serum concentrations of potassium, especially in children, in whom stool potassium losses are higher than in adults. Bicarbonates are effective in correcting the metabolic acidosis caused by diarrhoea and dehydration.