Atropine sulfate, Diphenoxylate HCl
Indications
Atropine sulfate, Diphenoxylate HCl is used for:
ATROPINE
For the treatment of poisoning by susceptible organophosphorous nerve agents having anti-cholinesterase activity (cholinesterase inhibitors) as well as organophosphorous or carbamate insecticides
DIPHENOXYLATE
For as adjunctive therapy in the management of diarrhea
For the treatment of poisoning by susceptible organophosphorous nerve agents having anti-cholinesterase activity (cholinesterase inhibitors) as well as organophosphorous or carbamate insecticides
DIPHENOXYLATE
For as adjunctive therapy in the management of diarrhea
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Atropine sulfate, Diphenoxylate HCl :
Mechanism of Action
ATROPINE
Atropine binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects
DIPHENOXYLATE
Diphenoxylate is an opiate receptor agonists that stimulate mu receptors in gi to decrease the peristalsis and constrict the sphincters. Diphenoxylate has a direct effect on circular smooth muscle of the bowel, that conceivably results in segmentation and prolongation of gastrointestinal transit time. The clinical antidiarrheal action of diphenoxylate may thus be a consequence of enhanced segmentation that allows increased contact of the intraluminal contents with the intestinal mucosa
Atropine binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects
DIPHENOXYLATE
Diphenoxylate is an opiate receptor agonists that stimulate mu receptors in gi to decrease the peristalsis and constrict the sphincters. Diphenoxylate has a direct effect on circular smooth muscle of the bowel, that conceivably results in segmentation and prolongation of gastrointestinal transit time. The clinical antidiarrheal action of diphenoxylate may thus be a consequence of enhanced segmentation that allows increased contact of the intraluminal contents with the intestinal mucosa