Azatadine maleate, Pseudoephedrine sulphate

Indications

Azatadine maleate, Pseudoephedrine sulphate is used for: AZATADINE
For the relief of the symptoms of upper respiratory mucosal congestion in perennial and allergic rhinitis, and for the relief of nasal congestion and eustachian t. B. Congestion
PSEUDOEPHEDRINE
For the treatment of nasal congestion, sinus congestion, eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Azatadine maleate, Pseudoephedrine sulphate :

Mechanism of Action

AZATADINE
Antihistamines such as azatadine appear to compete with histamine for histamine h1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of h1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release
PSEUDOEPHEDRINE
Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors