Azatadine Nasal prep

Indications

Azatadine Nasal prep is used for: Runny nose, sneezing, itching or blocked nose caused by allergies, such as pollen (hayfever), house dust mites or pet hair.

Adult Dose

Nasal Spray 1 spray in each nostril, every 12 hours as necessary.

Child Dose

Renal Dose

Administration

Blow your nose first. Remove the protective cap. Before first using, press the pump 2-3 times until an even spray emerges. Spray once into each nostril tilting head forward (look at toes). Do not keep head upright or tilted backwards. Sniff slowly and gently. Wipe the nozzle and replace the protective cap. Prime the pump again if you have not used the spray for 3 or more days.

Contra Indications

Neonates; patients receiving MAOI therapy; lactation.

Precautions

Angle-closure glaucoma, increased intraocular pressure, stenosing peptic ulcer, pyloroduodenal obstruction, epilepsy; renal and hepatic impairment. May impair ability to drive or operate machinery; pregnancy.

Pregnancy-Lactation

Interactions

Potentiates CNS depression with other CNS depressants e.g. TCAs, procarbazine and alcohol. Potentially Fatal: MAOIs enhance anticholinergic side effect of azatadine. Enhance depressant action of anxiolytic and sedating drugs.

Adverse Effects

Side effects of Azatadine Nasal prep : Drowsiness, dizziness, headache, fatigue, nervousness; anticholinergic effects, thick bronchial secretions; arthralgia; pharyngitis; increased appetite, wt gain, nausea, diarrhoea, abdominal pain, dry mouth; impaired alertness.

Mechanism of Action

Azatadine has anticholinergic and antiserotonin activity. It inhibits mediator release from mast cells by preventing calcium entry through voltage-dependent calcium channels.