Bambuterol Hydrochloride
Indications
Bambuterol Hydrochloride is used for:
Chronic obstructive pulmonary disease (COPD), Asthma.
Adult Dose
Adult: PO 10-20 mg/day at bedtime.
Hepatic impairment: Severe: Not recommended.
Child Dose
Renal Dose
Renal impairment:
CrCl (ml/min)
<50 Initial dose should be halved.
Administration
Contra Indications
Severe hepatic impairment; cirrhosis.
Precautions
DM, hyperthyroidism, myocardial insufficiency, arrhythmias, susceptibility to QT-interval prolongation. Pregnancy.
Pregnancy-Lactation
Interactions
Risk of hypokalaemia increased by co-admin of corticosteroids, diuretics or xanthines. Prolong the action of drugs e.g. suxamethonium.
Adverse Effects
Side effects of Bambuterol Hydrochloride :
Fine tremor of skeletal muscle (e.g. hands), palpitations and muscle cramps; tachycardia, tenseness and peripheral vasodilation.
Mechanism of Action
Bambuterol HCl is a prodrug of terbutaline. It relaxes bronchial smooth muscle by selectively acting on ?2-receptors.