Bambuterol Hydrochloride

Indications

Bambuterol Hydrochloride is used for: Chronic obstructive pulmonary disease (COPD), Asthma.

Adult Dose

Adult: PO 10-20 mg/day at bedtime. Hepatic impairment: Severe: Not recommended.

Child Dose

Renal Dose

Renal impairment: CrCl (ml/min) <50 Initial dose should be halved.

Administration

Contra Indications

Severe hepatic impairment; cirrhosis.

Precautions

DM, hyperthyroidism, myocardial insufficiency, arrhythmias, susceptibility to QT-interval prolongation. Pregnancy.

Pregnancy-Lactation

Interactions

Risk of hypokalaemia increased by co-admin of corticosteroids, diuretics or xanthines. Prolong the action of drugs e.g. suxamethonium.

Adverse Effects

Side effects of Bambuterol Hydrochloride : Fine tremor of skeletal muscle (e.g. hands), palpitations and muscle cramps; tachycardia, tenseness and peripheral vasodilation.

Mechanism of Action

Bambuterol HCl is a prodrug of terbutaline. It relaxes bronchial smooth muscle by selectively acting on ?2-receptors.