Betamethasone 0.05% + Calcipotriol 0.005% topical
Indications
Betamethasone 0.05% + Calcipotriol 0.005% topical is used for:
Psoriasis
Adult Dose
Adult: Topical : >18 yr: Apply once daily up to 4 wk. Max: 100 g/wk.
Child Dose
Renal Dose
Administration
Contra Indications
Known or suspected disorders of calcium metabolism. Patients with erythrodermic, exfoliative and pustular psoriasis.
Precautions
Not to be used on face, axillae or groin. Not to be applied to more than 30% of the body surface area. Monitor serum calcium levels; treatment should be temporarily discontinued if levels exceeded normal range. Prolonged usage or concurrent use with occlusive dressings may increase absorption of the drugs into the systemic circulation. Regular monitoring for evidence of hypothalamic-pituitary-adrenal axis suppression is recommended. Efficacy and safety have not been evaluated in patients with severe renal or hepatic impairment. Pregnancy and lactation.
Pregnancy-Lactation
Pregnancy
The limited data on use in pregnant women are not sufficient to evaluate associated risk for major birth defects, miscarriages, or adverse maternal or fetal outcomes; observational studies suggest an increased risk of having low birth weight infants with the maternal use of potent or very potent topical corticosteroids; advise pregnant women that therapy may increase potential risk of having a low birth weight infant and to use product on smallest area of skin and for shortest duration possible; in animal reproduction studies
Lactation
There is no information regarding presence of topically administered calcipotriene and betamethasone dipropionate in human milk, effects on breastfed infant, or on milk production; not known whether topically administered calcipotriene or corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed child from therapy or from underlying maternal condition; to minimize potential exposure to breastfed infant via breast milk, use drug on smallest area of skin and for shortest duration possible while breastfeeding; advise breastfeeding women not to apply drug directly to nipple and areola to avoid direct infant exposure
Interactions
Adverse Effects
Side effects of Betamethasone 0.05% + Calcipotriol 0.005% topical :
Pruritus, rash, burning sensation of the skin, dry skin, erythema, rash, dermatitis, eczema, photosensitivity and hypersensitivity reactions. May aggravate psoriasis.
Mechanism of Action
Betamethasone dipropionate is a synthetic corticosteroid that has anti-inflammatory, antipruritic and vasoconstrictive properties. Calcipotriol is a vitamin D analogue. It may induce differentiation and suppress proliferation of keratinocytes.