Betamethasone 0.05% + Lidocaine Hydrochloride 2.5%+ Phenylephrine Hydrochloride 0.1% (Rectal prep)
Indications
Betamethasone 0.05% + Lidocaine Hydrochloride 2.5%+ Phenylephrine Hydrochloride 0.1% (Rectal prep) is used for:
Discomfort, pain, itchiness or irritation around the anus, Haemorrhoids (piles)
Adult Dose
Apply to perianal region or rectally
May apply up to 2-4 times/day, especially at night, in the morning, or after bowel movement that may exacerbate hemorrhoid(s).
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity; systemic fungal or acute infections.
Precautions
Uncontrolled diabetes, peptic ulcer, osteoporosis, psychosis, psychoneurosis, pregnancy and lactation. Congestive heart failure, hypertension, epilepsy, CRF, elderly, regular monitoring of patients on long term therapy, withdraw gradually, glaucoma, hypothyroidism, cirrhosis, ocular herpes simplex, ulcerative colitis, infants and children.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Betamethasone 0.05% + Lidocaine Hydrochloride 2.5%+ Phenylephrine Hydrochloride 0.1% (Rectal prep) :
Topical application to the eye: Corneal ulcers, raised IOP and reduced visual acuity. Intradermal injection: Local hypopigmentation of deeply pigmented skin. Intra-articular injection: Joint damage, fibrosis, esp in load bearing joints.
Mechanism of Action
Betamethasone is a corticosteroid with mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein synthesis, depressing the migration of polymorphonuclear leukocytes and fibroblasts, and reversing capillary permeability and lysosomal stabilisation.
Lidocaine: Amide-type local anesthetic; reversibly block the initiation and conduction of nerve impulses by interfering with the flux of sodium ions though the neuronal membrane.
Phenylephrine: Alpha adrenergic agonist; elicits localized vasoconstriction and decreases inflammation .