Betamethasone 0.1% E/E & Nasal prep

Indications

Betamethasone 0.1% E/E & Nasal prep is used for: Allergic and inflammatory conditions of the eye, ear & nose.

Adult Dose

Adults Eye: 1 or 2 drops to each affected eye every 1 or 2 hours until control is achieved, then the frequency may be reduced. Ear: 2 or 3 drops to each affected ear every 2 or 3 hours until control is achieved, then the frequency may be reduced. Nose: 2 or 3 drops instilled into each nostril 2 or 3 times daily.

Child Dose

Children Eye: 1 or 2 drops to each affected eye every 1 or 2 hours until control is achieved, then the frequency may be reduced. Ear: 2 or 3 drops to each affected ear every 2 or 3 hours until control is achieved, then the frequency may be reduced. Nose: 2 or 3 drops instilled into each nostril 2 or 3 times daily.

Renal Dose

Administration

Contra Indications

Hypersensitivity; systemic fungal or acute infections.

Precautions

Uncontrolled diabetes, pregnancy and lactation. Elderly, regular monitoring of patients on long term therapy, withdraw gradually, glaucoma, hypothyroidism, ocular herpes simplex, infants and children.

Pregnancy-Lactation

Interactions

Increased hyperglycaemia and hypokalaemia with thiazide diuretics. Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs admin. Response to anticoagulants altered. Dose of antidiabetics and antihypertensives needs to be increased. Decreases serum conc of salicylates and antimuscarinic agents. Potentially Fatal: Reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone, barbiturates and rifampicin. Enhanced effect in women taking oestrogens or oral contraceptives.

Adverse Effects

Side effects of Betamethasone 0.1% E/E & Nasal prep : Corneal ulcers, raised IOP and reduced visual acuity.

Mechanism of Action

Betamethasone is a corticosteroid with mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein synthesis, depressing the migration of polymorphonuclear leukocytes and fibroblasts, and reversing capillary permeability and lysosomal stabilisation.