Betaxolol 0.25% Eye prep
Indications
Betaxolol 0.25% Eye prep is used for:
Glaucoma, Ocular hypertension
Adult Dose
Ophthalmic
Open-angle glaucoma
Adult: Instil 1 drop of 0.25% solution bid.
Ocular hypertension
Adult: Instil 1 drop of 0.25% solution bid.
Child Dose
Ophthalmic
Open-angle glaucoma
Child: Instil 1 drop of 0.25% solution bid.
Ocular hypertension
Child: Instil 1 drop of 0.25% solution bid.
Renal Dose
Administration
Contra Indications
Hypersensitivity. Sinus bradycardia, cardiogenic shock, overt cardiac failure. Pregnancy .
Precautions
DM, renal or hepatic impairment. May mask signs of hypoglycemia & hyperthyroidism. Gradual withdrawal is recommended. Children. Lactation.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Excretion in milk unknown; use with caution
Interactions
Increased risk of bradycardia w/ digitalis glycosides. May cause mydriasis w/ epinephrine. Potential additive effect w/ oral Ca channel blockers, ?-adrenergic blockers, antiarrhythmics (including amiodarone), parasympathomimetics, guanethidine. Increased risk of myocardial depression and hypotension w/ peripheral muscle relaxants (e.g. tubocurarine).
Adverse Effects
Side effects of Betaxolol 0.25% Eye prep :
>10%
Ocular effects
Short term discomfort (<25%)
Frequency Not Defined
Ocular
Blurred vision, Corneal punctate keratitis, Itching and/or foreign body sensation erythema, Inflammation, Ocular pain and/or discharge, Ocular drynes, Photophobia
Systemic
Bradycardia, congestive heart failure, heart block, Depression, dizziness, headache, insomnia, lethargy, vertigo, Hair loss, hives, toxic epidermal necrolysis
Glossitis, Bronchospasm, dyspnea, Increase in signs and symptoms of myasthenia gravis
Mechanism of Action
Betaxolol is a cardioselective Beta-blocker which has greater affinity for ?1-receptors and has little or no effect on ?2-receptors. It lacks intrinsic sympathomimetic but has little membrane-stabilising activity. It also causes the reduction of intraocular pressure by decreasing the production of aqueous humour.