Bimatoprost 0.03% Eye prep

Indications

Bimatoprost 0.03% Eye prep is used for: Open-angle glaucoma, Ocular hypertension

Adult Dose

Adult: Ophth Open-angle glaucoma; Ocular HTN As 0.03% soln: Instill 1 drop once nightly.

Child Dose

Renal Dose

Administration

Contra Indications

Known hypersensitivity.

Precautions

May increase pigmentation of the iris, periorbital tissue and eyelashes. Active intraocular inflammation. Safety and efficacy have not been evaluated in the treatment of inflammatory, neovascular or angle closure glaucoma. Ensure at least an interval of 5 minutes between admin of ophthalmic preparations. Contact lenses should be removed prior to admin. Pregnancy, lactation. Lactation: Excretion in milk unknown; use with caution

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Bimatoprost 0.03% Eye prep : >10% Conjunctival hyperemia (25-45%), Growth of eyelashes (15-45%), Ocular pruritus (15-45%) 1-10% Ocular dryness (3-10%), Visual disturbance (3-10%), Ocular burning (3-10%), Foreign body sensation (3-10%), Ocular pain (3-10%), Pigmentation of the periocular skin (3-10%), Blepharitis (3-10%), Cataract (3-10%), Superficial punctate keratitis (3-10%), Eyelid erythema (3-10%), Ocular irritation (3-10%), Eyelash darkening (3-10%), Ocular discharge (1-3%), Tearing (1-3%), Photophobia (1-3%), Allergic conjunctivitis (1-3%), Asthenopia (1-3%), Increases in iris pigmentation (1-3%), Conjunctival edema (1-3%) Frequency Not Defined Periorbital erythema, Eye swelling, Eyelids: burning sensation, edema, irritation, pruritus, Iris hyperpigmentation, Lacrimation increased, Madarosis and trichorrhexis, Periorbital and lid changes associated with a deepening of the eyelid sulcus, Rash (including macular, erythematous, and pruritic limited to the eyelids and periorbital region), Skin discoloration (periorbital), Blurred vision

Mechanism of Action

Bimatoprost is a prostamide analogue with ocular hypotensive action. It is postulated to lower intraocular pressure by increasing outflow of aqueous humor through both the trabecular meshwork and uveoscleral routes.