Biperiden
Indications
Biperiden is used for:
Drug-induced extrapyramidal symptoms (but not tardive dyskinesias) and adjunctive treatment of parkinsonism.
Adult Dose
Drug–induced extrapyramidal symptoms, parkinsonism, by mouth, ADULT (as biperiden hydrochloride), initially 1 mg twice daily, increased gradually to 2 mg 3 times daily; usual maintenance dose 3–12 mg daily in divided doses.
Drug–induced extrapyramidal symptoms, parkinsonism, by IM injection or slow IV injection, ADULT (as biperiden lactate), 2.5–5 mg repeated as necessary to maximum 20 mg in 24 hours
Child Dose
Renal Dose
Administration
Contra Indications
Angle-closure glaucoma;
Untreated urinary retention;
Prostatic hypertrophy;
Myasthenia gravis;
GI obstruction.
Precautions
Elderly;
Cardiovascular disease;
Hepatic or renal impairment;
Avoid abrupt withdrawal;
Pregnancy and breastfeeding
Pregnancy-Lactation
Recommendations on the use of Biperiden in Pregnancy & Lactation:
There is limited experience with the use of Biperiden during pregnancy and lactation. There has been no documented report of significant adverse effects (Schaefer et al., 2015). It should be used only when the benefit outweighs potential risks.
Reference:
1. Schaefer, C., Peters, P., & Miller, R. K. (2015). Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment (Third Edition). Academic Press
Interactions
Adverse Effects
Side effects of Biperiden :