Bisacodyl
Indications
Bisacodyl is used for:
Constipation, Bowel evacuation
Adult Dose
Oral
Constipation
Adult: 5-10 mg at night, up to 20 mg may be given as necessary.
Bowel evacuation
Adult: Initially, 10-20 mg the night before the procedure followed by 10 mg rectal supp the next morning. Alternatively, 10 mg on each of the 2 nights before the procedure.
Child Dose
Oral
Constipation
Child: 4-10 yr 5 mg at night; >10 yr Same as adult dose.
Bowel evacuation
Child: 4-10 yr 5 mg the night before the procedure and 5 mg rectal supp the following morning; >10 yr Same as adult dose.
Renal Dose
Administration
Should be taken on an empty stomach. Take on an empty stomach for rapid effect. Do not take w/in 1 hr of antacids, milk or other dairy products.
Contra Indications
Acute surgical abdomen or intestinal obstruction, severe dehydration, faecal impaction, chronic use.
Precautions
Swallow the tab whole. Pregnancy; inflammatory bowel disease.
Lactation: Has not been detected in excreted milk; use with caution
Pregnancy-Lactation
Pregnancy
Plasma concentrations of the active metabolite BHPM are low following doses of 10 mg/day for 7 days; short term use is generally considered safe in pregnancy; avoid long term use
Lactation
Not detected
Interactions
Do not give antacids or milk within 1 hr of taking the drug (enteric coated).
Adverse Effects
Side effects of Bisacodyl :
Abdominal cramping, Electrolyte and fluid imbalance, Excessive diarrhea, Nausea, Rectal burning, Vertigo, Vomiting
Mechanism of Action
Bisacodyl acts mainly in the large intestine by increasng its motility to effect bowel evacuation.