Bismuth Subcitrate Potassium, Tetracycline Hydrochloride, Metronidazole
Indications
Bismuth Subcitrate Potassium, Tetracycline Hydrochloride, Metronidazole is used for:
BISMUTH SUBCITRATE
For the treatment of peptic ulcer and gastro-oesophageal reflux disease (gord)
METRONIDAZOLE
For the treatment of anaerobic infections and mixed infections, surgical prophylaxis requiring anaerobic coverage, clostridium difficile-associated diarrhea and colitis, helicobacter pylori infection and duodenal ulcer disease, bacterial vaginosis, giardia lamblia gastro-enteritis, amebiasis caused by entamoeba histolytica, acne rosacea (topical treatment), and trichomonas infections
TETRACYCLINE
Used to treat bacterial infections such as rocky mountain spotted fever, typhus fever, tick fevers, q fever, rickettsialpox and brill-zinsser disease. May be used to treat infections caused by chlamydiae spp. , b. Burgdorferi (lyme disease), and upper respiratory infections caused by typical (s. Pneumoniae, h. Influenzae, and m. Catarrhalis) and atypical organisms (c. Pneumoniae, m. Pneumoniae, l. Pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin
For the treatment of peptic ulcer and gastro-oesophageal reflux disease (gord)
METRONIDAZOLE
For the treatment of anaerobic infections and mixed infections, surgical prophylaxis requiring anaerobic coverage, clostridium difficile-associated diarrhea and colitis, helicobacter pylori infection and duodenal ulcer disease, bacterial vaginosis, giardia lamblia gastro-enteritis, amebiasis caused by entamoeba histolytica, acne rosacea (topical treatment), and trichomonas infections
TETRACYCLINE
Used to treat bacterial infections such as rocky mountain spotted fever, typhus fever, tick fevers, q fever, rickettsialpox and brill-zinsser disease. May be used to treat infections caused by chlamydiae spp. , b. Burgdorferi (lyme disease), and upper respiratory infections caused by typical (s. Pneumoniae, h. Influenzae, and m. Catarrhalis) and atypical organisms (c. Pneumoniae, m. Pneumoniae, l. Pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Bismuth Subcitrate Potassium, Tetracycline Hydrochloride, Metronidazole :
Mechanism of Action
METRONIDAZOLE
Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then covalently binds to dna, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death
TETRACYCLINE
Tetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30s ribosomal subunit, preventing binding of trna to the mrna-ribosome complex, and thus interfering with protein synthesis
Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then covalently binds to dna, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death
TETRACYCLINE
Tetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30s ribosomal subunit, preventing binding of trna to the mrna-ribosome complex, and thus interfering with protein synthesis