Brimonidine topical

Indications

Brimonidine topical is used for: Rosacea

Adult Dose

Rosacea Indicated for persistent facial erythema of rosacea Apply topically to face qDay

Child Dose

<18 years: Safety and efficacy not established

Renal Dose

Administration

Contra Indications

Hypersensitivity

Precautions

Caution with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, thromboangiitis obliterans, scleroderma, or SjÖgren’s syndrome Alpha-2 adrenergic agents can lower blood pressure; caution with severe or unstable/uncontrolled cardiovascular disease Serious adverse reactions may occur following accidental ingestion of alpha-2 agonists by children; keep out of reach of children Not for oral, ophthalmic, or intravaginal use Erythema involving areas of face previously not affected by erythema and areas (e.g., neck and chest) outside of treatment sites reported Treatment effect of topical gel may begin to diminish hours after application Increased frequency of flushing and/or erythema with flushing following gel application reported Pallor or excessive whitening at or outside application site, following treatment with topical gel.reported Allergic contact dermatitis reported Hypersensitivity reactions following gel application include angioedema, throat tightening, tongue swelling, and urticaria; Institute appropriate therapy and discontinue therapy, if clinically significant hypersensitivity reaction occurs

Pregnancy-Lactation

Pregnancy Category: C Lactation: Unknown if distributed in human breast milk

Interactions

Adverse Effects

Side effects of Brimonidine topical : 1-10% Flushing (10%) Erythema (8%) Nasopharyngitis (5%) Skin-burning sensation (4%) Increased intraocular pressure (4%) Headache (4%)

Mechanism of Action

Alpha-2 adrenergic agonist