Brompheniramine + Dextromethorphan + Phenylephrine
Indications
Brompheniramine + Dextromethorphan + Phenylephrine is used for:
Relief of Cold Symptoms
Adult Dose
Relief of Cold Symptoms
4 teaspoons (20 mL) PO q4hr; not to exceed 120 mL/24 hr
Child Dose
Relief of Cold Symptoms
<6 years
Not recommended
6-12 years
2 teaspoons (10 mL) PO q4hr
>12 years
4 teaspoons (20 mL) PO q4hr
Renal Dose
Administration
Contra Indications
Hypersensitivity
Asthma
< 2 years of age
Severe hypertension
Narrow-angle glaucoma
Symptomatic prostate hypertrophy
Bladder-neck obstruction
Stenosing peptic ulcer
Use within 14 days of MAO inhibitor therapy
Precautions
Brompheniramine: May cause significant confusional symptoms; not for administration to premature or full-term neonates
Dextromethorphan: Do not take for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; may decrease respiration rate
Phenylephrine: Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis
Pregnancy-Lactation
Pregnancy category: C
Lactation: excreted in breast milk; use caution
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Interactions
Adverse Effects
Side effects of Brompheniramine + Dextromethorphan + Phenylephrine :
Frequency Not Defined
Dizziness
Drowsiness
Dry mouth, throat, and nose
Thickening of mucus in nose or throat GI disturbances
Reflex tachycardia
Excitability
Restlessness
Headache
Hypertension
Severe peripheral and visceral vasoconstriction
Mechanism of Action
Brompheniramine: Competitively blocks histamine from binding to H1 receptors; significant antimuscarinic activity and penetrates CNS, which causes pronounced tendency to induce sedation
Dextromethorphan: Cough suppressant that acts centrally on the cough center in medulla
Phenylephrine: Vasoconstrictor & decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue; shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia