Brompheniramine + Dextromethorphan + Pseudoephedrine
Indications
Brompheniramine + Dextromethorphan + Pseudoephedrine is used for:
Relief of Nasal Congestion, Cough
Adult Dose
Relief of Nasal Congestion & Cough
Syrup: 2 mg/10mg/30mg)/5mL
2 teaspoonfuls (10 mL) PO q4hr; not to exceed 6 doses/day
Child Dose
Relief of Nasal Congestion & Cough
Syrup: 2 mg/10mg/30mg)/5mL
<6 months: Safety and efficacy not established
6 months to 2 years: As directed by physician
2-6 years: 1/2 teasponful (2.5 mL) PO q4hr; not to exceed 6 doses/day
6-12 years: 1 teaspoonful (5 mL) PO q4hr; not to exceed 6 doses/day
>12 years: 2 teaspoonfuls (10 mL) PO q4hr; not to exceed 6 doses/day
Renal Dose
Administration
Contra Indications
Hypersensitivity
Acute asthma attack
Severe hypertension
Coronary artery disease
Narrow-angle glaucoma
Symptomatic prostate hypertrophy
Bladder-neck obstruction
Stenosing peptic ulcer
Precautions
Brompheniramine: May cause significant confusional symptoms; not for administration to premature or full-term neonates
Dextromethorphan: Do not take for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; may decrease respiration rate
Pseudoephedrine: Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure
Pregnancy-Lactation
Pregnancy category: C
Lactation: excreted in breast milk/not recommended
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Interactions
Adverse Effects
Side effects of Brompheniramine + Dextromethorphan + Pseudoephedrine :
Frequency Not Defined
Dizziness
Drowsiness
Dry mouth, throat, and nose
Thickening of mucus in nose or throat
GI disturbances
Arrhythmia
Palpitations
Convulsion
Excitability
Tremor
Weakness
Mechanism of Action
Brompheniramine: Competitively blocks histamine from binding to H1 receptors; significant antimuscarinic activity and penetrates CNS, which causes pronounced tendency to induce sedation
Pseudoephedrine: Stimulates alpha-adrenergic receptors causing bronchodilation & vasoconstriction
Dextromethorphan: Cough suppressant that acts centrally on the cough center in medulla