Butoconazole vaginal prep
Indications
Butoconazole vaginal prep is used for:
Vulvovaginal candidiasis
Adult Dose
Vaginal
Vulvovaginal candidiasis
Adult: As 2% cream: Apply approx 5 g intravaginally for 3 consecutive nights or as a single dose.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity to drug
1st trimester of pregnancy
Precautions
Women w/ recurrent infections or those having 1st-time vag yeast infection. Childn <12 yr. Pregnancy and lactation. Patient Counselling May weaken latex or rubber products (e.g. condoms, vag contraceptive diaphragms), do not use w/in 72 hr of treatment. Avoid contact w/ eyes.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: not known if excreted in breast milk; use caution
Interactions
Adverse Effects
Side effects of Butoconazole vaginal prep :
Vulvovaginal burning, itching, soreness and swelling, pelvic or abdominal pain or cramping. Severe reversible thrombocytopenia. Rarely, headache, urinary frequency and burning, vulvovaginal discharge, irritation, stinging and odor.
Mechanism of Action
Butoconazole, a synthetic azole antifungal, is usually fungistatic in action but may have growth phase-dependent fungicidal activity at high concentrations or against very susceptible organisms. It exerts its fungistatic activity by interfering w/ ergosterol synthesis and altering cellular membranes. It also has some antibacterial activity against gm+ve organisms.