Calcium Chloride + Magnessium Chloride + Potassium chloride + Sodium chloride + Sodium acetate + Sodium citrate
Indications
Calcium Chloride + Magnessium Chloride + Potassium chloride + Sodium chloride + Sodium acetate + Sodium citrate is used for:
Irrigation Solution: For irrigation during various ocular surgical procedures. For use as an extraocular and intraocular irrigating solution during ocular surgical procedure involving perfusion of the eye with an expected maximum duration of less than 60 minutes.
Adult Dose
This irrigating solution should be used according to standard format for each surgical procedure.
Child Dose
This irrigating solution should be used according to standard format for each surgical procedure.
Renal Dose
Administration
Contra Indications
Known hypersensitivity to any of the ingredients of this preparation.
Precautions
Use with caution in diabetic patients undergoing vitrectomy since intraoperative lens changes have been observed. There have been reports of corneal clouding and edema following ocular surgery in which Irrigating Solution was used as an irrigating solution.
Not for injection or intravenous infusion. Do not uses unless product is clear, seal is intact, vacuum is present & container is undamaged. Do not use if product is discolored or contains a precipitate.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Calcium Chloride + Magnessium Chloride + Potassium chloride + Sodium chloride + Sodium acetate + Sodium citrate :
Irrigation or any other trauma may result in corneal swelling or bullous keratopathy. Post-operative inflammatory reactions as well as incidents of corneal edema and corneal decompensation have been reported.
Mechanism of Action
Calcium chloride is used to prevent or treat negative calcium balance. It also regulates action potential excitation threshold to facilitate nerve and muscle performance.
Potassium chloride is a major cation of the intracellular fluid. It plays an active role in the conduction of nerve impulses in the heart, brain and skeletal muscle; contraction of cardiac skeletal and smooth muscles; maintenance of normal renal function, acid-base balance, carbohydrate metabolism and gastric secretion.
Sodium chloride is the major extracellular cation. It is important in electrolyte and fluid balance, osmotic pressure control and water distribution as it restores sodium ions. It is used as a source of electrolytes and water for hydration, treatment of metabolic acidosis, priming solution in haemodialysis and treatment of hyperosmolar diabetes. It is also used as diluents for infusion of compatible drug additives.
Magnessium Chloride: Acts as cofactor in numerous enzymatic reactions involving protein synthesis and carbohydrate metabolism; depresses CNS, blocks peripheral neuromuscular transmission, produces anticonvulsant effects.
Sodium plays an important role in controlling the total body water and its distribution. Sodium is the main cation in the extracellular fluid and comprises >90% of total cations. The acetate component is an alternate source of bicarbonate by metabolic conversion in the liver.
Alkalinizes urine; citrate binds with urinary calcium.