Capsicin, Glycol salycilate, Histamine 2HCl, Mephenesin, Methyl nicotate
Indications
Capsicin, Glycol salycilate, Histamine 2HCl, Mephenesin, Methyl nicotate is used for:
CAPSAICIN
The capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain.
METHYL SALICYLATE
Temporary relief of minor aches and pains caused by arthritis, simple backache, strains, sprains, and bruises.
The capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain.
METHYL SALICYLATE
Temporary relief of minor aches and pains caused by arthritis, simple backache, strains, sprains, and bruises.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Capsicin, Glycol salycilate, Histamine 2HCl, Mephenesin, Methyl nicotate :
Mechanism of Action
CAPSAICIN
Capsaicin has been shown to reduce the amount of substance p associated with inflammation - however this is not believed to be its mechanism in pain relief. Capsaicin's mechanism of action is attributed to "defunctionalization" of nociceptor fibers by inducing a topical hypersensitivity reaction on the skin. This alteration in pain mechanisms is due to many of the following: temporary loss of membrane potential, inability to transport neurotrophic factors leading to altered phenotype, and reversible retraction of epidermal and dermal nerve fiber terminals.
Capsaicin has been shown to reduce the amount of substance p associated with inflammation - however this is not believed to be its mechanism in pain relief. Capsaicin's mechanism of action is attributed to "defunctionalization" of nociceptor fibers by inducing a topical hypersensitivity reaction on the skin. This alteration in pain mechanisms is due to many of the following: temporary loss of membrane potential, inability to transport neurotrophic factors leading to altered phenotype, and reversible retraction of epidermal and dermal nerve fiber terminals.