Carbetocin

Indications

Carbetocin is used for: Prophylaxis of uterine atony and excessive bleeding after caesarean section

Adult Dose

Intravenous Prophylaxis of uterine atony and excessive bleeding after caesarean section Adult: Single dose of 100 mcg given over 1 min after delivery.

Child Dose

Renal Dose

Administration

Contra Indications

Do not administer before delivery. Vascular disease esp coronary artery disease; hepatic or renal disease.

Precautions

Monitor BP in eclampsia and preeclampsia for up to 8 hrs. Inadequate uterine contraction (do not repeat treatment). Epilepsy; migraine; asthma.

Pregnancy-Lactation

Interactions

Vasoconstrictors in conjunction with caudal block anaesthesia; cyclopropane anaesthesia.

Adverse Effects

Side effects of Carbetocin : Nausea; vomiting; abdominal pain; pruritus; flushing; feeling of warmth; hypotension; headache; tremor; back pain; dizziness; metallic taste; anaemia; sweating; chest pain; dyspnoea; chills; tachycardia; anxiety.

Mechanism of Action

Carbetocin is a synthetic analogue of oxytocin reported to have a longer duration of action.