Carbinoxamine

Indications

Carbinoxamine is used for: Seasonal & perennial allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, urticaria & angioedema

Adult Dose

Allergies 4-8 mg PO q6-8hr PO; not to exceed 24 mg/day ER: 6-16 mg (7.5-20 mL) PO q12hr Other Indications & Uses Seasonal & perennial allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, urticaria & angioedema

Child Dose

Allergies 2-6 years: 0.2-0.4 mg/kg/day PO divided q6-8hr or 1-2 mg (2.5 mL) PO q6-8hr >6 years: 2-4 mg (5-7.5 mL) PO q6-8hr ER 2-3 years: 3-4 mg (3.75-5 mL) PO q12hr 4-5 years: 3-8 mg (3.75-10 mL) PO q12hr 6-11 years: 6-12 mg (7.5-15 mL) PO q12hr >12 years: 6-16 mg (7.5-20 mL) PO q12hr

Renal Dose

Administration

Contra Indications

Hypersensitivity Concurrency with MAO inhibitors Preemies & neonates Nursing mothers Lower respiratory tract symptoms, eg, asthma

Precautions

Narrow-angle glaucoma, prostatic hypertrophy, peptic ulcer, GI obstruction, bladder outflow obstruction, history of bronchial asthma, incr IOP, HTN, hyperthyroidism, cardiovascular dz May affect mental alertness Elderly

Pregnancy-Lactation

Pregnancy Category: C Lactation: excretion in milk unknown/contraindicated

Interactions

Adverse Effects

Side effects of Carbinoxamine : Frequency Not Defined CNS depression Drowsiness Sedation ranging from mild drowsiness to deep sleep (most frequent) Dizziness Lassitude Disturbed coordination Muscular weakness Restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitation, seizures is less common Epigastric distress Anorexia Nausea Vomiting Diarrhea Constipation Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice is rare Tachycardia, palpitation ECG changes (eg, widened QRS) Arrhythmias (eg, extrasystole, heart block) Hypotension Hypertension Dizziness, sedation, and hypotension may occur in geriatric patients Dryness of mouth, nose, and throat Dysuria Urinary retention Impotence Vertigo Visual disturbances Blurred vision Diplopia; tinnitus Acute labyrinthitis Insomnia Tremors Nervousness Irritability Facial dyskinesia Tightness of the chest Thickening of bronchial secretions Wheezing Nasal stuffiness Sweating Chills Early menses Toxic psychosis Headache

Mechanism of Action

Histamine H1-receptor antagonist in blood vessels, respiratory tract, and gastrointestinal tract