Carvedilol

Indications

Carvedilol is used for: Hypertension, Congestive heart failure, Myocardial infarction, Left ventricular dysfunction, Angina pectoris

Adult Dose

Congestive Heart Failure Immediate release 3.125 mg PO q12hr for 2 weeks, then increased every 2 weeks as tolerated to 6.25 mg, 12.5 mg, or 25 mg PO twice daily Maximum recommended dosage (mild-to-moderate heart failure): <85 kg, 25 mg PO q12hr; >85 kg: 50 mg PO twice daily Maximum recommended dosage (severe heart failure): 25 mg PO twice daily Extended release 10 mg/day PO; maintained for 1-2 weeks if tolerated; may be increased to 20 mg/day, 40 mg/day, or 80 mg/day PO if necessary Hypertension Immediate release: 6.25 mg PO twice daily initially; after 7-14 days, increased as tolerated, first to 12.5 mg PO twice daily and then to 25 mg PO twice daily Extended release: 20 mg/day PO; maintained for 1-2 weeks if tolerated; may be increased to 40 mg/day PO if necessary; not to exceed 80 mg/day PO Left Ventricular Dysfunction Following Myocardial Infarction Immediate release: 3.125-6.25 mg PO q12hr initially; after 3-10 days, increased as tolerated, first to 12.5 mg PO q12hr and then to 25 mg PO q12hr (target dosage) Extended release: 10-20 mg/day PO; increased every 3-10 days as tolerated up to 80 mg/day PO (target dosage) Angina pectoris 25-50 mg PO twice daily Hepatic impairment: Contraindicated in severe liver impairment

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment: No dosage adjustments necessary

Administration

Should be taken with food.

Contra Indications

Hypersensitivity; severe chronic heart failure, bronchial asthma or related bronchospastic conditions; severe hepatic impairment. Patients with NYHA class IV cardiac failure, 2nd or 3rd ° AV block, sick sinus syndrome (unless a permanent pacemaker is in place), cardiogenic shock or severe bradycardia. Lactation.

Precautions

Avoid abrupt withdrawal as it may precipitate thyroid storm or exacerbate hyperthyroidism. Liver injury; vascular disease, renal failures, suspected phaeochromocytoma and prinzmetal's variable angina; worsening cardiac failure or fluid retention during increase in dosage of carvedilol; diabetic patients. Pregnancy. Lactation: Unknown whether drug is excreted in milk; not recommended

Pregnancy-Lactation

Pregnancy Available data in pregnant women are insufficient to determine whether there are drug-associated risks of adverse developmental outcomes; there are risks to mother and fetus associated with poorly controlled hypertension in pregnancy; the use of beta blockers during third trimester of pregnancy may increase risk of hypotension, bradycardia, hypoglycemia, and respiratory depression in neonates; in animal reproduction studies, there was no evidence of adverse developmental outcomes at clinically relevant doses; observe newborns for symptoms of hypotension, bradycardia, hypoglycemia, and respiratory depression and manage accordingly Hypertension in pregnancy increases maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications (e.g., need for cesarean section and post-partum hemorrhage); hypertension increases fetal risk for intrauterine growth restriction and intrauterine death; pregnant women with hypertension should be carefully monitored and managed accordingly Lactation There are no data on presence of carvedilol in human milk, effects on breastfed infant, or on milk production; drug is present in the milk of lactating rats; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infant from treatment or from underlying maternal condition

Interactions

Decreased serum levels w/ rifampicin. Combination w/ Ca channel blockers (e.g. verapamil and diltiazem) can lead to bradycardia and myocardial depression. Potentiates insulin-induced hypoglycaemic action. May increase hypoglycaemic effects of antidiabetic agents. Increased risk of bradycardia w/ digoxin. Increased risk of hypotension and bradycardia w/ reserpine, MAOIs, clonidine. May increase ciclosporin concentrations. Concurrent use w/ ether, cyclopropane, trichloroethylene may increase the risk of hypotension and heart failure.

Adverse Effects

Side effects of Carvedilol : >10% Dizziness (2-32%), Fatigue (4-24%), Hypotension (9-20%), Weight gain (10-12%), Hyperglycemia (5-12%), Diarrhea (1-12%) 1-10% Bradycardia (2-10%), Nausea (2-9%), Cough (5-8%), Headache (5-8%), Atrioventricular block, edema (1-7%), Angina (1-6%), Hpercholesterolemia (1-4%), Hypertriglyceredemia (1%), Vomiting (1-6%), Dyspnea (>3%), Syncope (3%), Rhinitis (2%) Frequency Not Defined Hypertension, Palpitations, Insomnia, Somnolence, Skin rash, Hepatotoxicity, Impotence, Bronchospasm, Rales, Depression, Decreased exercise tolerance, Raynaud phenomenon, Increased triglyceride levels and insulin resistance with decreased high-density lipoprotein (HDL) levels

Mechanism of Action

Carvedilol is a nonselective beta-adrenoreceptor and alpha-adrenergic blocking activity. It exerts antihypertensive effect partly by reducing total peripheral resistance and vasodilation.