Cefetamet Pivoxil Hydrochloride

Indications

Cefetamet Pivoxil Hydrochloride is used for: Pneumonia, Pharyngitis, Susceptible infections, Sinusitis, Otitis media, Tonsillitis, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis, Gonococcal urethritis

Adult Dose

Adults: 500 mg twice daily.

Child Dose

Children over 12 years: 500 mg twice daily. Children under 12 years: Usual dosage is 10 mg/kg twice daily. <15 kg (approximately 6 months - 3 years) 125 mg twice daily 16 - 30 kg (approximately 3 - 9 years) 250 mg twice daily 31 - 40 kg (approximately 9 - 12 years) 375 mg twice daily >40 kg (approximately over 12 years) 500 mg twice daily

Renal Dose

Administration

Contra Indications

Known hypersensitivity to cephalosporins.

Precautions

Hypersensitivity to penicillins. Renal insufficiency; lactation.

Pregnancy-Lactation

Pregnancy Available data from published observational studies, case series, and case reports over several decades with cephalosporin use, including cefixime, in pregnant women have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes Maternal gonorrhea may be associated with preterm birth, low neonatal birth weight, chorioamnionitis, intrauterine growth restriction, small for gestational age and premature rupture of membranes; perinatal transmission of gonorrhea to offspring can result in infant blindness, joint infections, and bloodstream infections Lactation There are no available data on presence of drug in human milk, effects on breastfed infant, or on milk production; drug is present in animal milk; when a drug is present in animal milk, it is likely the drug will be present in human milk; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infant from drug or from mother’s underlying condition

Interactions

Adverse Effects

Side effects of Cefetamet Pivoxil Hydrochloride : Diarrhoea, nausea, vomiting, hypersensitivity reactions.

Mechanism of Action

Cefetamet is a 3rd generation cephalosporin. It inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs).