Cefprozil
Indications
Cefprozil is used for:
Pharyngitis, Susceptible infections, Sinusitis, Otitis media, Skin and skin structure infections, Tonsillitis, Respiratory tract infections, Acute Maxillary Sinusitis, Acute bacterial exacerbation of chronic bronchitis
Adult Dose
Pharyngitis & Tonsillitis
500 mg PO qDay for 10 days
Respiratory Tract Infections, Skin Infections
250-500 mg q12hr OR 500 mg qDay for10 days
Child Dose
Child: PO 15–30 mg/kg/day q12h
Renal Dose
Renal impairment:
CrCl (ml/min)
<30 Half normal dose.
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypersensitivity.
Precautions
Hypersensitivity to penicillins; renal impairment; porphyria. Monitor renal and haematologic status. Pregnancy, lactation.
Lactation: low distribution into breast milk; use with caution
Pregnancy-Lactation
Pregnancy Category: B
Lactation: low distribution into breast milk; use with caution
Interactions
Renal excretion delayed by probenecid. Decreases contraceptive effect of oestrogen-containing oral contraceptives.
Adverse Effects
Side effects of Cefprozil :
1-10%
Nausea (3.5%), Diarrhea (2.9%), Elevated LFTs (2%), Diaper rash (1.5%), Abdominal pain (1%), Dizziness (1%), Vomiting (1%)
<1%
Eosinophilia, Superinfection, Vaginitis, Cholestatic jaundice, Elevated BUN & creatinine, Prolonged PT
Potentially Fatal: Pseudomembranous colitis.
Mechanism of Action
Cefprozil inhibits cell wall synthesis and has activity against a broad range of gram-positive and gram-negative bacteria.