Chloramphenicol 0.5% Eye drops
Indications
Chloramphenicol 0.5% Eye drops is used for:
Bacterial Conjunctivitis
Adult Dose
Ophthalmic
Ocular infections
Adult: Instill 1 drop every 2 hr. Increase dosage interval upon improvement. To continue treatment for at least 48 hr after complete healing.
Reduce dose once symptoms are controlled or apply a 1% ointment 3-4 times daily.
Hepatic impairment: Dose reduction may be required.
Child Dose
Renal Dose
Renal impairment: Dose reduction may be required.
Administration
Contra Indications
History of hypersensitivity or toxic reaction to the drug; Herpes simplex and other virul conditions of the eye or ear, mycosis.
Precautions
Avoid prolonged use. Discontinue immediately if local hypersensitivity reactions occur.
Pregnancy-Lactation
Interactions
Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives.
Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function.
Adverse Effects
Side effects of Chloramphenicol 0.5% Eye drops :
Ophthalmic application: Hypersensitivity reactions including rashes, fever and angioedema.
Mechanism of Action
Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.