Chlordiazepoxide, Clidinium bromide
Indications
Chlordiazepoxide, Clidinium bromide is used for:
CHLORDIAZEPOXIDE
For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety
CLIDINIUM
For the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome
For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety
CLIDINIUM
For the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Chlordiazepoxide, Clidinium bromide :
Mechanism of Action
CHLORDIAZEPOXIDE
Chlordiazepoxide binds to stereospecific benzodiazepine (bzd) binding sites on gaba (a) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. This results in an increased binding of the inhibitory neurotransmitter gaba to the gaba(a) receptor. Bzds, therefore, enhance gaba-mediated chloride influx through gaba receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties
CLIDINIUM
Inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites primarily by inhibiting the m1 muscarinic receptors
Chlordiazepoxide binds to stereospecific benzodiazepine (bzd) binding sites on gaba (a) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. This results in an increased binding of the inhibitory neurotransmitter gaba to the gaba(a) receptor. Bzds, therefore, enhance gaba-mediated chloride influx through gaba receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties
CLIDINIUM
Inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites primarily by inhibiting the m1 muscarinic receptors