Chlorhexidine Gluconate 0.2% Gargle
Indications
Chlorhexidine Gluconate 0.2% Gargle is used for:
Gingivitis, Mouth sore
Adult Dose
Adult: Mouth/throat Oral hygiene; Gingivitis As 0.2% soln: Rinse w/ 10 mL for about 1 min bid.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Avoid contact w/ middle ear or sensitive tissues and eyes. Do not inject or use in body cavities.Avoid eating, drinking, or brushing your teeth just after using this medication
Pregnancy-Lactation
Interactions
Soaps, other anionic agents, borates, bicarbonates, carbonates, chlorides, citrates, nitrates, phosphates & sulfates.
Adverse Effects
Side effects of Chlorhexidine Gluconate 0.2% Gargle :
Skin sensitivity; mucosal irritation; reversible brown staining of the teeth; tongue discoloration and burning sensation; transient taste disturbance; parotid gland swelling.
Potentially Fatal: Anaphylaxis.
Mechanism of Action
Chlorhexidine is a very potent cationic chemoprophylactic agent that has a broad-spectrum of activity against gm+ve and gm-ve bacteria. It is both bacteriostatic and bactericidal depending on its concentration. The bactericidal effect, which is achieved at high concentrations, is due to the binding of the cationic to negatively charged bacterial cell walls and extramicrobial complexes. Bacteriostatic effect is achieved at low concentrations which causes an alteration of bacterial cell osmotic equilibrium and leakage of potassium and phosphorus.