Chlorhexidine Gluconate 1 % vag prep
Indications
Chlorhexidine Gluconate 1 % vag prep is used for:
Use in obstetrics as a vaginal lubricant & for application to the vulva & perineum during labour.
Adult Dose
Topical/Cutaneous
As antiseptic and disinfectant
Adult: As cream or solution: Apply to skin or to the affected area.
Child Dose
Renal Dose
Administration
To be applied liberally to the skin on and around vulva, to hand, prior to vaginal application
Contra Indications
Hypersensitivity
Precautions
Avoid contact w/ brain, meninges, middle ear or sensitive tissues and eyes. Do not inject or use in body cavities.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Chlorhexidine Gluconate 1 % vag prep :
Skin sensitivity; irritation of conjunctiva, mucosal irritation; reversible brown staining of the teeth; tongue discoloration and burning sensation; transient taste disturbance; parotid gland swelling.
Potentially Fatal: Anaphylaxis.
Mechanism of Action
Chlorhexidine is a very potent cationic chemoprophylactic agent that has a broad-spectrum of activity against gm+ve and gm-ve bacteria. It is both bacteriostatic and bactericidal depending on its concentration. The bactericidal effect, which is achieved at high concentrations, is due to the binding of the cationic to negatively charged bacterial cell walls and extramicrobial complexes. Bacteriostatic effect is achieved at low concentrations which causes an alteration of bacterial cell osmotic equilibrium and leakage of potassium and phosphorus.